Methyl CpG®

Methyl CpG® is a comprehensive formula that includes targeted amounts of five key nutrients designed to support methylation and homocysteine balance in the body.
Methylation is a vitamin-requiring biochemical process in the body that is critical for supporting many aspects of mental and physical health including regulating gene expression. Methylation occurs billions of times every second and helps the body to repair DNA on a continual basis. However, when methylation processes in the body slow down, an increase in the breakage of DNA strands can occur. In addition to maintaining DNA repair, methylation reactions help maintain optimal neurotransmitter production, homocysteine balance for cardiovascular health, and the recycling of molecules that are required for detoxification and healthy inflammatory response. Methylation is also required for proper energy metabolism, immune and nerve cell function. Proper methylation can be inhibited by nutrient deficiencies including folate, and B2, B6 and B12. Certain medications such as acetaminophen, aspirin, ibuprofen and oral contraceptives can also deplete blood levels of these crucial B vitamins.
Methyl CpG® provides high-concentration folate as Quatrefolic®- 100% 5-MTHF, the biologically active form, and trimethyl glycine. The formula includes key methylation vitamins B2, B6 and B12 (methylcobalamin). This specific blend of methyl donors promotes DNA repair, homocysteine balance, neurotransmitter production, hormone balance and optimal detoxification.
Ortho Molecular Products' logo, text, trademarks, graphics, and photo images are the property of Ortho Molecular Products, Inc. and are used with permission. Copyright © 2026.
*FDA Disclaimer: The information about this product and statements made are provided by the manufacturer, except customer reviews which are not evaluated. See www.orthomolecularproducts.com for information about the relationship between this product and any claims made. Results may vary from person to person based on body size and other factors, and the effectiveness is not guaranteed for you. Always seek the advice of your healthcare professional about taking dietary, nutritional, herbal or homeopathic supplements.
Methyl CpG® is a comprehensive formula that includes targeted amounts of five key nutrients designed to support methylation and homocysteine balance in the body.
Methylation is a vitamin-requiring biochemical process in the body that is critical for supporting many aspects of mental and physical health including regulating gene expression. Methylation occurs billions of times every second and helps the body to repair DNA on a continual basis. However, when methylation processes in the body slow down, an increase in the breakage of DNA strands can occur. In addition to maintaining DNA repair, methylation reactions help maintain optimal neurotransmitter production, homocysteine balance for cardiovascular health, and the recycling of molecules that are required for detoxification and healthy inflammatory response. Methylation is also required for proper energy metabolism, immune and nerve cell function. Proper methylation can be inhibited by nutrient deficiencies including folate, and B2, B6 and B12. Certain medications such as acetaminophen, aspirin, ibuprofen and oral contraceptives can also deplete blood levels of these crucial B vitamins.
Methyl CpG® provides high-concentration folate as Quatrefolic®- 100% 5-MTHF, the biologically active form, and trimethyl glycine. The formula includes key methylation vitamins B2, B6 and B12 (methylcobalamin). This specific blend of methyl donors promotes DNA repair, homocysteine balance, neurotransmitter production, hormone balance and optimal detoxification.
Ortho Molecular Products' logo, text, trademarks, graphics, and photo images are the property of Ortho Molecular Products, Inc. and are used with permission. Copyright © 2026.
*FDA Disclaimer: The information about this product and statements made are provided by the manufacturer, except customer reviews which are not evaluated. See www.orthomolecularproducts.com for information about the relationship between this product and any claims made. Results may vary from person to person based on body size and other factors, and the effectiveness is not guaranteed for you. Always seek the advice of your healthcare professional about taking dietary, nutritional, herbal or homeopathic supplements.
1 capsule per day or as recommended by your health care professional.