A trio of supplements that support optimal methylation*Thorne’s Methylation Bundle contains the supplements Methyl-Guard Plus®, BioMins II®, and D-5,000 to support optimal methylation throughout the body.*The human body is extremely complex, with various biological switches that must function and operate in an ideal fashion. Methylation is the body’s mechanism that turns these biological switches on and off for a host of body systems. When optimal methylation occurs, it has a significant positive impact on many biochemical pathways in the body involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, fertility, and redox balance.  Thorne’s Methylation Bundle contains three supplements that support optimal methylation.*Methyl-Guard Plus®, Thorne’s most popular methylation supplement, contains betaine (also called trimethylglycine), 5-MTHF (active folate), methyl-B12 (active vitamin B12), P5P (active vitamin B6), and R5P (active vitamin B2) to promote healthy methylation for cardiovascular, cognitive, bone health, and more.*BioMins II® is a comprehensive multiple mineral formula, without copper and iron. Its formula contains highly absorbable mineral chelates made by Albion Laboratories.* BioMins II provides the minerals needed as nutrient cofactors for optimal methylation to occur in numerous biochemical pathways.* D-5,000 provides 5,000 IUs of vitamin D per capsule. Vitamin D is an essential nutrient for one of the pathways involved in homocysteine metabolism and methylation.* In addition to supporting healthy bones and muscles, vitamin D supports cardiovascular health and immune function.* Thorne's logo, text, trademarks, graphics, videos and photo images are the property of Thorne and are used with permission. Copyright © 2023*FDA Disclaimer: The information about this product and statements made are provided by the manufacturer, except customer reviews which are not evaluated. See www.thorne.com for information about the relationship between this product and any claims made. Results may vary from person to person based on body size and other factors, and the effectiveness is not guaranteed for you. Always seek the advice of your healthcare professional about taking dietary, nutritional, herbal or homeopathic supplements.