Why you'll love SPM Active^®

Get back to feeling like yourself. SPM Active® delivers specialized pro-resolving mediators (SPMs): concentrated nutrients from omega-3 fish oil that target the root causes of soreness, not just the symptoms. Clinical research showed a decrease in joint soreness and discomfort intensity in 2 weeks.*^††

Whether it's joint discomfort, post-exercise recovery, or everyday aches, this SPM supplement helps your body bounce back so you can keep moving freely.

• Targets soreness at the source, not just the symptoms*
• 36% felt less sore in 2 weeks; 81% less joint discomfort at 3 months*^†
• Eases everyday soreness and supports joint health*
• Helps you bounce back after physical activity or daily stress*
• Next-generation fish oil with concentrated SPMs
• Friend of the Sea Certified ensuring responsible sourcing and environmental protection
• Satisfaction Guaranteed: Love it within 60 days or your money back

Want a convenient single-softgel option? Try SPM Active One Daily.

The Science Inside SPM Active^®

Your body naturally produces specialized pro-relieving mediators (SPMs) to help ease soreness and support recovery. But as we age, our SPM levels drop, and that's when muscle and joint discomfort start to add up.

SPM Active^® gives your body more of what it needs. These natural compounds from omega-3 fish oil help your body ease soreness rather than simply masking symptoms.*

What to expect with consistent use:

• 14 days: Helps ease everyday soreness so you can move more freely.*^†
• 1 month: 77% of people felt less joint discomfort.^†
• 8 weeks: Improvements in mood, mental clarity, stress, and fatigue.*

Specialized Pro-Resolving Mediators (SPMs) — Natural compounds that help your body ease soreness and support lasting joint health.*

How Are SPMs Different from Traditional EPA/DHA Omega-3 Fish Oils?

While EPA and DHA fish oil supplements support foundational wellness by supplying essential fatty acids for overall health, SPM Active^® is designed for targeted support. Derived from omega-3 fatty acids, it delivers bioactive specialized pro-resolving mediators (SPMs) that are already pre-converted, meaning they do not require the same metabolic conversion as traditional fish oil.* This allows SPM Active^® to support your body's natural inflammation resolution pathways more efficiently, helping ease minor joint discomfort and support faster recovery after physical stress or exercise.*

Triple tested. Practitioner trusted.

For over 40 years, Metagenics^® has led innovation in health supplements, exceeding industry standards for transparency and accountability. We guarantee that what’s on the label is what’s in the bottle, and that commitment is why we’re trusted by more than 50,000 healthcare providers worldwide. This, and all our formulas are also:

• Produced in GMP certified facilities to meet the highest quality standards.
• Science-backed: We perform +200K quality tests annually, from ingredient sourcing to finished product, for accuracy and consistency.
• Triple tested: All our products are verified for identity, purity, strength, and stability at three levels of production: ingredient, formula, and encapsulation.
• Metagenics is the #1 Doctor-Recommended Professional Supplement Brand^★ trusted by 50,000 healthcare practitioners.
• Environmentally Responsible: As a registered B-Corp, sustainability matters; all our products are made ethically, responsibly, and with purpose.
• Risk Free: Every purchase is backed by our 60-Day Money Back Guarantee.

Allergen Information

Contains fish | Non-GMO | Gluten-Free | Sugar-Free | Lactose-Free