Does GABA really relax and rejuvenate?

Reducing stress levels often feels good and can give us a new perspective on life. It’s no wonder that a group of antidepressants known as SSRIs are so widely used. However, given the well-documented side effects associated with long-term antidepressant use, many people wonder whether there are natural solutions that can provide similar benefits in a healthier, more sustainable way.

One of the most popular natural relaxants is GABA (gamma-aminobutyric acid), an amino acid that is naturally produced in the body but may be deficient in some people. GABA has been associated with benefits such as improved mood, reduced premenstrual syndrome (PMS) symptoms, and support for attention deficit/hyperactivity disorder (ADHD).

Studies show that when the body has adequate GABA levels, brain waves shift in a way that reduces anxiety, increases feelings of well-being, and improves sleep quality. A newer study even suggests that increasing GABA levels may restore youthful flexibility to the adult brain. But can these effects truly be achieved through supplementation?

How Does GABA Work?

Research shows that individuals with balanced GABA levels tend to fare better mentally and emotionally. A study published in Biological Psychiatry found that correcting GABA imbalances boosts alpha brain wave production, which is associated with relaxation and reduced stress.

The brain produces different types of electrical activity known as brain waves. Alpha waves are linked to relaxed mental states and often increase during meditation, yoga, or even when closing the eyes briefly.

When GABA levels are too low, the brain produces excessive beta waves. While beta waves are necessary for focus and problem-solving, too many can lead to anxiety, mental fatigue, and stress.

Excessive beta wave activity, which is more common in adults, can make it difficult to quiet the mind. Higher GABA levels help moderate beta waves, promoting a calmer and more balanced mental state.

The same study noted that many pharmaceutical treatments for mood disorders focus on neurotransmitters like serotonin and dopamine but fail to address GABA imbalances. GABA appears to play a critical role in fine-tuning mood, thoughts, and behavior.

Can GABA Help With Anything Else?

Researchers at Thomas Jefferson University Hospital found that adequate GABA levels not only ease anxiety but also support healthy sleep. Low GABA allows beta waves to dominate, leading to racing thoughts and difficulty falling asleep.

From a physiological standpoint, the body struggles to enter deep delta sleep without sufficient GABA. Addressing this imbalance may help prevent insomnia-related mood disorders.

An intriguing study from UC Irvine showed that GABA-producing neurons restored brain plasticity in adult mice, allowing them to learn new tasks more easily. This flexibility, common in children, declines with age.

By increasing GABA activity, researchers reactivated the brain’s ability to adapt and form new neural connections. If future research confirms these findings in humans, GABA-based therapies may one day support learning, recovery from brain injury, and treatment of certain neurological disorders.

Do GABA Supplements Work?

Scientists are divided on whether oral GABA supplements can cross the blood-brain barrier. Some argue the body prefers to produce its own GABA, while others believe high-dose supplementation may reach the brain.

One proven way to support natural GABA production is by consuming foods rich in glutamic acid. The amino acid L-glutamine is a direct precursor to GABA.

Foods such as almonds, walnuts, halibut, whole grains, rice bran, and lentils provide glutamic acid and help the body create its own GABA more efficiently.

Some individuals report benefits from oral GABA supplementation. If you wish to try it, consider GABA by Pure Encapsulations. Another option is supporting the body’s own GABA production with Kavinace OS by NeuroScience.

I hope this information is useful. If you have questions about this topic or anything else, contact our customer service team at customerservice@oakwaynaturals.com or call 888-460-3091.

Yours in health,

Dr. Gregg Gittins

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Reducing our stress levels certainly feels good, and often gives us a new perspective on life, so it’s no wonder that a certain group of anti-depressants (known as SSRIs) are so popular. But in light of the widely-reported side effects with the long-term use of anti-depressants, are there natural solutions that do the same thing in a healthier, more sustainable way?

One of the most popular natural relaxants is GABA; an amino acid that is naturally produced in our bodies but is deficient in some of us. GABA has been found to improve mood, reduce symptoms of premenstrual syndrome (PMS) and treat attention deficit hyperactivity disorder (ADHD).

A number of studies show that, when we have enough of it, GABA alters brain waves in such a way that anxiety is reduced, feelings of well-being are increased, and we sleep better at night.

A new study even indicates that increasing GABA levels in the brain can restore youthful flexibility to the adult brain. While the potential is exciting, can you expect such results through GABA supplementation, or are the claims mostly just hype?

The brain produces different types of electrical activity known as brain waves; alpha waves are considered a sign of relaxed activity in the brain and are commonly felt after activities like meditation or yoga.

Without proper GABA levels, the brain produces too many beta waves – which are associated with alert cognitive tasks and mental activities but take a tremendous amount of energy. This is problematic because, although moderate levels of beta waves are what help us solve puzzles or find the answer to a tough math problem, too many of them increases our stress and anxiety.

Excessive beta wave activity, which is more common in adults than children, often leaves us unable to block out excessive brain activity that may make us feel worried or sad. Higher levels of GABA appear to moderate these beta waves down to a more reasonable and useful quantity.

The researchers in this study found that common pharmaceuticals that attempt to fix mood disorders, like anxiety, don’t work as intended because they only fix imbalances in neurotransmitters such as serotonin and dopamine; not GABA imbalances. The study claims that GABA is part of the brain system that allows us to fine-tune our moods, thoughts, and actions with an incredible level of detail.

When there is too little GABA in the brain, those beta waves take over and it causes the racing thoughts that characterize anxiety and can keep you up at night.

Scientifically speaking, the body has trouble entering the “deep” delta sleep (which usually begins 45 minutes after you fall asleep) without sufficient GABA. Addressing this problem can keep those struggling with sleep from developing insomnia-related mood disorders.

There’s even an intriguing new study that shows GABA may help us defy the “old dogs can’t learn new tricks” saying. Neurobiologists at UC Irvine transplanted a certain type of embryonic neuron into the brains of adult mice with the hopes that it could restore the flexibility of their brains. The transplanted neurons express GABA and, remarkably, it seems that the experiment had its intended effect that old mice learned new tricks more quickly!

The tests successfully restored youthful flexibility to the adult brains, known as brain plasticity, allowing the brains to make the rapid and robust changes in neural pathways and synapses that happen when juveniles learn and experience new things.

The problem with all of this is that science is conflicted on whether oral GABA supplements are able to cross the blood-brain barrier and make these changes to our brain. Many researchers say that the body prefers to make its own GABA and, as a result, it is hard for supplemental GABA to go from the blood to the brain. However, others say that GABA supplements at high enough doses can reach the brain.

There is also a big difference between mice and humans, but the research continues. Only time will tell if GABA supplements are worthy of the hype around them but, in the meantime, here is a tip for increasing the amount of GABA your body produces on its own – eat foods containing high levels of  glutamic acid.

The amino acid l-glutamine is what directly leads (precursor) to the creation of GABA in the body. Foods like almonds, walnuts, halibut, whole grain oats and wheat, rice bran, and lentils all contain high levels of glutamic acid that give the body what it needs to create its own GABA that can more easily reach the brain.

There are those who say that oral GABA supplementation has helped them, though, so if you would like to try it for yourself, I recommend Pure Encapsulations’ GABA. An alternative approach would be to use a high-quality product that gives the body what it needs to make its own GABA, such as Kavinace by NeuroScience.

We hope this slide show was helpful and informative. Should you have questions, or suggestions, please feel free to fill out our Ask the Doctor form found at the Doctors Corner.

Yours in health,

Dr. Gregg Gittins

www.oakwaynaturals.com

Levinson, Andrea, MD, et al., Biological Psychiatry: Critical brain chemical shown to play role in depression. 2010 Gandhi, Sunli, Ph.D. University of California – Irvine: Neurobiologists restore youthful vigor to adult mouse brains. 2015 Petroff, Ognen, MD, Neuroscientist: GABA and glutamate in the human brain. 2002